- Pds1 / Esp1 Mutants
- pds1∆
- pds1∆ in nocodazole
- bub2∆ pds1∆ in nocodazole
- mad2∆ pds1∆ in nocodazole
- cdc20∆ pds1∆
- cdc20∆ pds1∆ clb5∆
- CLB5-db∆ pds1∆
- CLB5-db∆ pds1∆ cdc20∆
- CLB1 clb2∆ pds1∆
- esp1-ts
- GAL-PDS1-db∆ esp1-ts
- GAL-PDS1-db∆
- PDS1-db∆
- GAL-ESP1 cdc20-ts
CLB5-db∆ pds1∆ cdc20∆
debug: ,
test user =
test db =
Simulation:
Change of parameters: kdb5"=0, ks1pds"=ks2pds"=0,
ks20'=ks20"=0.
Length of G1 phase: 34.5 min.
Arrest: Telophase arrest.
Experiments:
Wasch, R. and Cross, F. (2002). APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit. Nature 418:556-562.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Fig. 1, telophase arrest.
Comments: This shows that Cdc20 has other essential targets beside Clb5 and Pds1, namely Clb2.
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